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Check out our CONCACAF Champions Cup Betting Odds! In the first leg of the CONCACAF Champions Cup semifinal fixtures, Cruz Azul did what they needed to do on the road, locking up Tigres UANL in a 1-1 draw.
If they can force a scoreless draw at home, they would advance on the strength of that away goal. Given their propensity for offense – and the desperation that Tigres will bring on the road, with that away goal tiebreaker hanging over them, though, expect to see some offense.
In the other semifinal, the Vancouver Whitecaps may have blinked in earlier home leg opportunities, leaving themselves with way much work to do on the road, but that was not the case against Inter Miami as they rolled over the Herons, 2-0, in front of their fans.
Now Inter have a massive hole to climb out of just to force a potential shootout, let alone make it to the final.
CONCACAF Champions Cup Betting Odds: Semifinal Leg 2 Preview & Schedule
We have sports betting previews for each of these showdowns, so read on before you lock in any wagers.
Inter Miami (-200) vs Vancouver Whitecaps (+490) (Draw +350)
Vancouver lead on aggregate, 2-0
When: Wednesday, April 30, 8:00 pm ET
FC Dallas had only scored 10 goals in nine MLS matches going into their weekend tilt in Miami, but they pushed that total to 14 in a 4-3 shocker over the Herons, whose defense turned ridiculous over the course of the night.
That followed the 2-0 loss up in Vancouver in Champions Cup play and suggests that there is some serious work to do on the Inter back line.
Inter Miami have also won all three of the Cup games they have hosted this season. But can they overcome a stretch of just two wins in seven matches across all competitions?
They have a fairly rested and healthy Lionel Messi (who you can get on +300 odds to score the first goal of the match) and Luis Suarez.
Those two have the talent to get the Herons not just on the board but also through to the Cup final, if they can break through Vancouver.
Vancouver continued their MLS-leading ways this past weekend, rolling over Minnesota, 3-1, thanks to tallies from substitutes Sebastian Berhalter and Pedro Vite. Berhalter also scored in the first-leg win over Inter, along with Brian White.
The Whitecaps’ clean sheet in the first leg was a bit of a departure, as no team in the Cup had allowed more than the eight goals that they have. Inter Miami, have managed 11 goals in the tournament, second only to the 14 that Cruz Azul have scored.
However, the Whitecaps have an eight-match unbeaten streak with four wins, across all competitions. Even if they lose 3-1 here, they would advance on the away goal tiebreaker.
So I like Vancouver to employ a more conservative approach and for Inter to get the result in the leg – but the Whitecaps to advance. Inter Miami to win.
^CONCACAF Champions Cup Betting Odds provided by Xbet
Cruz Azul (-101) vs Tigres UANL (+270) (Draw +250)
Tied on aggregate, 1-1
When: Thursday, May 1, 10:00 pm ET
The hosts welcome Tigres while riding a 15-match unbeaten streak (8 wins) across all competitions. In their last four games, three have ended in draws, but they also beat Liga MX rival Club America, 2-1, in the Cup quarterfinals last month.
Cruz Azul have just one loss in their last 13 Champions Cup matches. Cruz have struggled historically against Tigres, winning just once in their last six tries, but that win did come at home in February 2024.
Tigres arrive on the momentum of a seven-match unbeaten streak across all competitions (3 wins).
Interestingly, three of those matches have ended in scoreless draws. In the quarterfinals, they sent LAFC home, 3-2 on aggregate.
However, they have a seven-match winless streak on the road in Champions Cup play (2 losses).
The road has been a hard place for them to score, as they have not tallied a goal in four of their last five away matches across all competitions. Cruz Azul to win.
^Locked in for the Semifinals!
— Concacaf Champions Cup (@TheChampions) April 10, 2025
Inter Miami vs Vancouver
Cruz Azul vs Tigres pic.twitter.com/FES1D7y2CF
Read if you want the Semifinals Prediction for Leg 1
Historically, Liga MX has dominated the CONCACAF Champions Cup, but this year’s semifinal round includes just two teams from Mexico’s first division and two teams from Major League Soccer.
We have three nations represented in the last four for the first time in five years, when Honduran club C.D. Olimpia made it this far.
MLS has had two other teams win this trophy – LA Galaxy and Seattle Sounders. Canadian sides CF Montreal and Toronto FC have made it to the final.
CONCACAF Champions Cup Betting Odds: Semifinal Leg 1 Preview & Schedule
So who will navigate their way to the trophy this time? First, we have a two-leg semifinal tie to sort out. We have sports betting previews of the first leg, as well as some thoughts on the eventual winner.
Tigres UANL (+116) vs Cruz Azul (+244) (Draw +228)
When: Wednesday, April 23, 10:00 pm ET
Vancouver Whitecaps (+123) vs Inter Miami (+199) (Draw +248)
When: Thursday, April 24, 10:30 pm ET
Rundown of the Tournament: Favorites? Upsets? Surprises?
Tigres
They have the most experience in this tournament of the remaining four. They are also coming out of a reasonably successful Liga MX Clausura campaign, where they finished fourth and will advance to the playoffs. They’ve also dealt with the most recent change in leadership – it’s barely been a month since Guido Pizzaro was promoted from player to manager. Another veteran, André-Pierre Gignac, almost 40 years old, is the top scorer for Tigres in Liga MX with seven tallies. They also beat Cruz Azul in the Clausura campaign, 2-1. They’ve also beaten Miami recently (2-1, back in August 2024) and Vancouver, winning four of five showdowns over the last eight years. But are they the favorites? Actually, they would be a surprise to win if they can push through, based on the other teams.
Vancouver
Whitecaps lead the MLS standings as well as some key statistical categories. This is a team that focuses on possession. Getting by Inter Miami will be another gauntlet, but the Whitecaps are led by Brian White’s nine tallies in 14 goals in all competition this year, as well as defensive midfielder Andres Cubas, who is one of the few players in the world that has managed to keep Lionel Messi in check. But until they beat Inter Miami, they won’t be the favorite.
Cruz Azul
Mexican team has a strong chance to get this trophy. They won the Liga MX Apertura season before struggling in the early part of the Clausura. However, they finished with three wins in their last five contests and came in third ahead of the playoffs. Their offense has a lot of contributors – in a 17-match Clausura season, five different players had at least five goals. Angel Sepulveda led the way with nine. They’ve already stopped Seattle Sounders and the tournament favorites, Club America, in the quarterfinal. They’re a hot team right now – the hottest of the four.
On paper, Inter Miami are the favorites
They have four players who have won UEFA Champions League titles – Messi, Luis Suarez, Jordi Alba, and Sergio Busquets. Changing to Javier Mascherano as head coach has led to a bit of a drop in 2025 – they drew in MLS play against Toronto FC and Chicago Fire FC, and they barely beat the Columbus Crew. However, this is a team that has stayed focus in the CONCACAF Champions Cup. They are the favorites on paper, but I’m leaning toward Cruz Azul at this point.
Leg 2 Schedule
Inter Miami vs Vancouver Whitecaps
When: Wednesday, April 30, 8:00 pm ET
Cruz Azul vs Tigres UANL
When: Thursday, May 1, 10:00 pm ET
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CONCACAF Champions Cup Betting Odds, Semifinals Leg 2
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