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The first leg of the CONCACAF Champions Cup quarter finals mostly consisted of wasted opportunities by favored teams.
Three of the four quarter final matches ended up tied, and the fourth was a significant upset. The most shocking outcome came from Los Angeles as LAFC shut down Inter Miami, 1-0.
LAFC began their MLS season with two victories but faltered, losing three of four matches before facing Inter. In a stunning upset, Nathan Ordaz scored the decisive goal in a 1-0 victory, but momentum shifted as they lost 1-0 to Houston Dynamo.
Now, they travel to Miami for the next match. Meanwhile, the L.A. Galaxy, winless in their first six MLS games, managed a surprising scoreless draw against a strong Liga MX team. However, they couldn’t capitalize, losing to Real Salt Lake afterward.
Even so, they head to Mexico all square with a shot to get to the semifinals.
CONCACAF Champions Cup Prediction and Betting Quarterfinals – Leg 2 Schedule with Odds and Picks
What can we expect this time around? Don’t miss our sports betting thoughts on each game as well as our thoughts about the potential cup winner.
Tigres UANL (-230) vs L.A. Galaxy (+650) (Draw +330)
Tied on aggregate, 0-0
When: Tuesday, April 8, 9:00 pm ET
Champions Cup Pick: Tigres to win
Tigres
They had their CONCACAF Champions Cup run end last year in the quarter finals as the Columbus Crew prevailed, 4-3, on penalties. In general, though, Tigres have done quite well all-time against MLS sides, with just four losses in 28 meetings across all competitions. Tigres have a four-match unbeaten streak in Champions Cup play (two wins and two draws). They have only lost once in their last 12 home Champions Cup fixtures, and that was the aforementioned loss on penalties to Columbus last year. They have also won seven of their last nine home Champions Cup matches against MLS teams, with a loss and a draw. They should have some room to operate against the Galaxy after taking such a conservative approach in the first leg.
LA Galaxy
The Galaxy now have a five-match winless streak across all competitions after that disappointing 2-0 loss at Real Salt Lake. They have failed to put a ball in their opponents’ net for two straight matches now. They have struggled against Liga MX sides, with just six wins and 12 losses in 20 meetings (with two draws). They have just one win in their last 10 competitive games, and in the Champions Cup, they have just one win in their last seven fixtures. In their last six away games in the Champions Cup, they have two draws and four losses, allowing four or more goals in three of those games.
^Cruz Azul (+160) vs Club America (+174) (Draw +222)
Tied on aggregate, 0-0
When: Tuesday, April 8, 11:30 pm ET
Champions Cup Pick: Cruz Azul to win
Cruz Azul
They picked up an impressive road draw against the Liga MX Clausura leaders in the first leg. They beat Pumas UNAM, 3-2, at home in Liga MX play over the weekend behind a brace from Carlos Rotondi and a stoppage-time goal in the first half from Andres Montano. Cruz Azul now have a 10-game unbeaten streak across all competitions and a six-game unbeaten streak in the Champions Cup, including three wins and four clean sheets.
Club America
The teams also failed to score over the weekend, losing at Pachuca, 1-0, in Liga MX play. They hadn’t lost in five games across all competitions last year, and it was Pachuca that sent them home from last year’s Champions Cup in a 3-2 semifinal win on aggregate. Of the 178 prior meetings between these venerable Mexico City sides, Club America have 66 wins, while Cruz Azul have 49, with an eye-popping 63 draws. Their last four meetings have led to one win apiece and two draws. They’ve failed to combine for more than two goals in five of their last seven meetings. They do have time to collect themselves ahead of the Clausura playoffs, but Cruz Azul are playing better in league play as well as in Cup play right now.
^Inter Miami (-181) vs LAFC (+440) (Draw +330)
LAFC lead on aggregate, 1-0
When: Wednesday, April 9, 8:00 pm ET
Champions Cup Pick: Inter Miami to win
Los Angeles FC
They have made it to two CONCACAF Champions Cup finals already, despite only having been a franchise for eight seasons. They lost to Tigres in the 2020 final and Club Leon in the 2023 final. If they can somehow get by Inter on the road, they would get to the semifinals. They stopped Colorado in the first round and then avenged loss to Columbus in the 2023 MLS Cup and the 2024 Leagues Cup, turning a 3-0 win in the first leg into a 4-2 win on aggregate. Their recent away form is worrying, though, as they have lost three of four away matches in MLS play, including that 1-0 loss in Houston as Jack McGlynn scored for the Dynamo, the only name on the scoresheet.
Luis Suarez and Lionel Messi
Both stars started for Inter Miami and played all 90 minutes, but neither could score. Suarez struggled with only 38 touches, the lowest of any field player, and failed to get any shots on target. The team possessed 59% of the match but couldn’t find the net. They were eliminated in last year’s quarterfinals by Monterrey but have had a solid start to the MLS season, winning four of six matches. This weekend, they drew with Toronto FC, conceding a goal before Messi equalized. Atlanta United remains the only team to win at Inter Miami recently.
^CONCACAF Champions Cup Prediction provided by Xbet
Pumas UNAM (-109) vs Vancouver Whitecaps (+285) (Draw +260)
Tied on aggregate, 1-1
When: Wednesday, April 9, 10:30 pm ET
These two teams played to a draw up in Canada last week as Vancouver benefited from an own goal from Nathan Silva in the second half. The Whitecaps could not hold onto that gift, though, conceding the equalizer to Adalberto Carraquilla.
Pumas last reached this stage in the CONCACAF Champions Cup in 2022, defeating New England Revolution on penalties. The Whitecaps reached this point last year but lost 6-0 to LAFC. Pumas has a win and a draw against Vancouver in their previous meetings, while Vancouver is winless in six against Liga MX teams.
Mexican team boast three Champions Cups and two runner-up finishes, while the Whitecaps have never advanced past the semifinals since 2016, lacking away wins this season. Despite Pumas’ recent struggles, they have a chance to capitalize at home after Vancouver’s missed opportunity.
^CONCACAF Champions Cup Prediction: Who Will Win?
In a crucial quarterfinal match, Club America and Cruz Azul, the top contenders for the cup, face off. Club America leads Liga MX despite recent struggles, but Cruz Azul performed better in the first leg with an away draw. Both teams have shown superiority over others, with Cruz Azul gaining confidence from their defense. If Club America wins, they could reclaim the favorite status in this competitive matchup.
^Inter Miami
Inter Miami faces pressure going into the second leg against LAFC, who previously held Messi and Suarez scoreless in Los Angeles despite their struggles in MLS. LAFC’s strong CONCACAF Champions League performance under Steve Cherundolo means they only need an away draw or can lose by one goal, provided they score. While LAFC plays liberatingly, they might struggle against Liga MX teams if they advance past Inter Miami, presenting a challenging path ahead.
^What about Inter Miami?
Despite ranking highly in CONCACAF and having Messi, the Herons aren’t meeting Supporters’ Shield standards in MLS this season. Their performance in the upcoming second leg against LAFC will be revealing. A decisive 2-0 or 3-0 win at home could boost their credibility heading into the semifinals.
^L.A. Galaxy
Galaxy capitalized on Tigres’ conservative strategy in the home match. Observing Tigres’ performance in Mexico is crucial; early struggles could indicate trouble. While advancing seems unlikely for Galaxy, they might expose weaknesses in Tigres, challenging their contender status.
^Liga MX Teams
Pumas and Tigres find themselves in similar predicaments. Pumas managed to secure a draw in Vancouver due to a significant misstep by the Whitecaps, who allowed an own goal and failed to capitalize on opportunities. Vancouver’s inability to secure a win could prove costly, as Pumas now benefits from an away goal. Despite Vancouver’s strong start in MLS, they squandered a chance against a Liga MX team. While Pumas might advance, doubts linger about either team’s ability to overcome Club America or Cruz Azul.
^¡El Clásico Joven desde CU! ️
— Concacaf Champions Cup (@TheChampions) April 8, 2025
Cruz Azul o América, ¿Quién avanzará a Semis? pic.twitter.com/fvnLLzJqBM
CONCACAF Champions Cup Prediction: 2025 Quarterfinals Leg 1
Let’s take a look at the CONCACAF Champions Cup prediction, quarterfinal schedule, as well as each team’s chances to win the whole thing, as you plan for your soccer sports betting this week.
We’ve had a couple of weeks since the round of 16 of the CONCACAF Champions Cup, but now that the international break is over, it’s time for the quarterfinals. MLS has four teams left, the same number as Liga MX.
CONCACAF Champions Cup Prediction, Betting Quarterfinals, Leg 1 Schedule with Odds
The quarterfinals consist of two legs, and now that we’re down to the last eight, the Cinderella teams have all been sent home.
All eight remaining teams have made deep runs in this tournament before, and each of them would love to add this cup to their trophy racks.
Club America (+113) vs Cruz Azul (+232) (Draw +244)
When: Tuesday, April 1, 9:15 pm ET
Champions Cup Pick: Take the draw
These teams also squared off in the semifinals of Liga MX’s Apertura playoffs in December. Club America picked up a 4-3 nailbiter on aggregate. They also look like a smart pick in the 2025 Clausura season after rolling over Tigres UANL, 3-0, on Saturday. They have a six-match unbeaten streak in Liga MX play (4 wins, 2 draws) since they lost to Club Necaxa, 3-2, in February. Club America already sent one Liga MX side home in the round of 16 after stopping Guadalajara, 4-1, on aggregate.
Cruz Azul have their offense rolling in the knockout rounds. In the round of 32, they routed Haitian side Real Hope, 7-0, and then they stopped the Seattle Sounders, 4-1, on aggregate in the round of 16. They beat Guadalajara, 1-0, in Liga MX play on Saturday and are in fifth in the Clausura table – but just five points back of first-place Club America. A win here would make a significant statement. Club America have just lost once in their last eight home matches, with five wins and two draws. However, Cruz Azul have just lost once in their last 15 matches, home and away, across all competitions, with 10 wins and four draws.
LA Galaxy (+165) vs Tigres UANL (+155) (Draw +244)
When: Tuesday, April 1, 11:15 pm ET
Champions Cup Pick: Tigres UANL to win
LA Galaxy’s struggles in 2025 continue. In MLS, they have yet to win a match in six tries (two draws and four losses). They lost to Orlando City SC on Sunday, 2-1, and now they have permitted 12 goals while scoring just five. In the CONCACAF Champions Cup round of 16, they took on Costa Rican side Herediano and advanced, 4-2, on aggregate.
Tigres UANL look to bounce back from that 3-0 whipping they took from Club America on Saturday. That ended a three-match winning streak in Liga MX play in which they scored six goals while posting two clean sheets. They narrowly beat Real Esteli in the round of 32 and then sent MLS team FC Cincinnati home in the round of 16, winning, 4-2 on aggregate. Given the struggles that LA Galaxy have shown when playing quality opposition, this is frankly a surprising moneyline.
Vancouver Whitecaps (-103) vs Pumas UNAM (+265) (Draw +260)
When: Wednesday, April 2, 9:30 pm ET
Champions Cup Pick: Vancouver to win
Vancouver is the unlikely leaders in the MLS Western Conference table after posting 13 points in six games. They show an intrepid defense, solid chemistry, and real finishing ability. They beat Monterrey away, tied them at home, and advanced on the strength of away goals. With Ryan Gauld on the shelf, the offense is starting to take on water, but Brian White has stepped in, with three goals in four matches.
Pumas are one of the storied teams in Liga MX, with seven league titles and a roster filled with talent. However, they are just in 10th place in the Clausura table, taking 17 points out of 13 games. They did stop LD Alajuelense, 3-1, on aggregate in the CONCACAF Champions Cup Round of 16, and they did stop third-place Leon in Liga MX play this weekend. Those are signs that Pumas could be rounding back into form, but Vancouver has earned respect in this home fixture.
LAFC (+149) vs Inter Miami (+171) (Draw +246)
When: Wednesday, April 2, 11:30 pm ET
Champions Cup Pick: Take the draw
Inter Miami decisively defeated Jamaican side Cavalier 4-0 on aggregate in the round of 16, clinching both matches 2-0 without Lionel Messi. In March, they enjoyed a perfect record, winning all six competitive fixtures and earning points in eight of their last nine games, with the only blemish being a 2-2 draw against New York City FC. Last year, they exited the quarterfinals to Monterrey but have never lost a CONCACAF Champions Cup tie against MLS teams, having also eliminated Sporting Kansas City and Nashville SC.
LAFC sent Columbus Crew home in the round of 16, winning 4-2 on aggregate. That was particularly satisfying as the Crew sent LAFC home from the last Leagues Cup and kept them from winning their second straight MLS Cup in 2023. However, in MLS play, LAFC have dropped four of five, including a 3-2 home loss to San Diego FC on Saturday. They have yet to lose at home in CONCACAF Champions Cup play. They have a 2-1 all-time record against Inter Miami, although they haven’t beaten them at home since 2020.
CONCACAF Champions Cup Prediction & Quarterfinals Power Rankings
8. LA Galaxy
In 2025, the LA Galaxy became the first reigning MLS Cup champion to start a season with six winless matches. Lacking roster strength, chemistry, and health, the team’s chances for success seem bleak, raising doubts about their dignity in the quarterfinals.
7. LAFC
The Black and Gold come in the wake of a 3-2 loss to MLS expansion team San Diego FC. Because of injuries to Olivier Giroud and Jeremy Ebobisse, they had to move attacker Denis Bouanga to the center instead of out on the wing, which took away from his usual offensive contributions. Getting a tie with Inter Miami brings MLS’ top team right now in at the wrong time.
6. Pumas UNAM
This is a team that has coasted through a favorable draw in the CONCACAF Champions Cup. Beating Canadian Premier League team Cavalry in the round of 32 and Costa Rican side LD Alajuelense was expected, but now they head to Vancouver to take on a team that is playing with house money, on the rise in MLS.
5. Vancouver Whitecaps
The Whitecaps began their MLS season by winning four straight games. Although they have slowed their pace, they eliminated Monterrey in the round of 16 with an alternate team. Midfielder Ryan Gauld is injured, but is expected to return. If they advance to the semifinals, they could spring a surprise.
4. Tigres UANL
Juan Brunetta has six goals in 13 games in Liga MX Clausura play. Tigres will also benefit from having a lot of their own fans when they play at Dignity Health Sports Park. LA Galaxy shouldn’t be a problem for Tigres to get by – but what will happen when they see Club America or Cruz Azul in the semis?
3. Cruz Azul
The quarterfinal tilt with Club America is a significant test. But Cruz Azul have been hot since the calendar turned to 2025. If they can get through, they’d have to be a solid co-favorite to win the whole thing.
2. Club America
This side lead the Clausura standings with 30 points in 13 standings. Victor Davila, Alejandro Zendejas and Alvaro Fidalgo have led the team with five goals, and Luis Angel Malagon has been a brick wall in goal. Club America have seven CONCACAF Champions Cup titles and have the experience and roster to win an eighth.
1. Inter Miami
The Herons beat the only other elite Eastern Conference team in MLS when they stopped Philadelphia, 2-1, this past weekend. Lionel Messi will be back for this trip with his team, although given Inter’s likelihood of stopping LAFC, he may not play. Just having him on the bench will boost his team.
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CONCACAF Champions Cup Prediction, Quarterfinals Leg 2 Odds
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